μ Opioid Receptor/MOR Agonist

μ Opioid Receptor/MOR Agonists (34):

Cat. No.	Product Name	Effect	Purity

HY-P0210

DAMGO	Agonist	99.90%
DAMGO is a μ-opioid receptor (μ-OPR ) selective agonist with a K_d of 3.46 nM for native μ-OPR.

HY-N0164

Matrine	Agonist	≥98.0%
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI).

HY-164747

Isotodesnitazene	Agonist	99.78%
Isotodesnitazene is a kind of opioids. Isotodesnitazene primarily acts on μ-opioid receptors (MOR). Isotodesnitazene has an EC₅₀ of 34.8 nM for MOR-βarr2 and 142 nM for MOR-mini-Gi. Isotodesnitazene can be used in the study of opioids.

HY-170342

KOR agonist 3	Agonist
KOR agonist 3 (Compound 5) is a κ opioid receptor (κOR) agonist with an EC₅₀ of 0.88 nM. KOR agonist 3 also has a certain activation effect on μOR with an EC₅₀ of 720 nM. KOR agonist 3 shows no agonist activity for δOR at concentrations less than 1 μM. KOR agonist 3 has a lower ability to induce the recruitment of β-Arrestin-2 than U50488 (HY-15997B).

HY-120645

BMS-986122	Agonist	99.94%
BMS-986122 is a selective, potent positive allosteric modulator of the mu-opioid receptor (μ-OR). BMS-986122 shows potentiation of orthosteric agonist-mediated β-arrestin recruitment, adenylyl cyclase inhibition, and G protein activation. BMS-986122 potentiates DAMGO-mediated [³⁵S]GTPγS binding in mouse brain membranes.

HY-P0185

Endomorphin 1	Agonist	99.92%
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties.

HY-P0244

Dermorphin	Agonist	99.96%
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.

HY-101386

PZM21	Agonist	99.46%
PZM21 is a potent and selective μ opioid receptor agonist with an EC₅₀ of 1.8 nM.

HY-N0923

Corydaline	Agonist	99.70%
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.

HY-P0186A

Endomorphin 2 TFA	Agonist	99.43%
Endomorphin 2 TFA, a high affinity, highly selective agonist of the μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i value between 20 and 30 nM.

HY-P1087

Adrenorphin	Agonist
Adrenorphin is a opioid octapeptide, acting as a potent agonist of μ-opioid receptor, with K_i of 12 nM.

HY-P0210B

DAMGO TFA	Agonist	99.60%
DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a K_d of 3.46 nM for native μ-OPR.

HY-104006

CYM51010	Agonist	99.12%
CYM51010 is a biased ligand of μ-opioid receptor – δ-opioid receptor heterodimers with an EC₅₀ of 403 nM. CYM51010 exhibits anti-nociceptive activity similar to morphine but with a decreased levels of tolerance development and withdrawal symptoms.

HY-111454

SR17018	Agonist	98.01%
SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC₅₀ of 97 nM.

HY-P0185A

Endomorphin 1 acetate	Agonist	99.92%
Endomorphin 1 acetate, a high affinity, highly selective agonist of the μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i value between 20 and 30 nM. Endomorphin 1 acetate has antinociceptive properties.

HY-B0380

Trimebutine	Agonist	99.40%
Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.

HY-P1866A

β-Endorphin, equine TFA	Agonist
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties.

HY-139678

SC13	Agonist
SC13 is a novel mitragynine analog with low-efficacy Mu opioid receptor agonism that displays antinociception with attenuated adverse effects.

HY-151811

NAQ	Agonist
NAQ is a potent and selective μ opioid receptor partial agonist, with a K_i of 0.55 nM. NAQ shows selectivity for Mu opioid receptor over the δ receptor (K_i=132.50 nM) and the κ receptor (K_i=26.45 nM). NAQ can be used for the research of opioid withdrawal or dependence.

HY-P4107

Bilaid C	Agonist
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (K_i=210 nM, hMOPr).

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